IgG Whey Protein

Balancing intestinal flora

A total of 100 trillion diverse bacteria live in our intestines in a well-balanced manner, creating an ecosystem like a microcosm called the “intestinal flora”. When viewed under a microscope, they look like a field of flowers, so they came to be called “intestinal flora.” The intestinal bacteria that form the intestinal flora can be broadly classified into three groups: good bacteria, bad bacteria, and opportunistic bacteria. If for some reason the balance of intestinal bacteria is disrupted and bad bacteria in the intestines become dominant, harmful substances produced by bad bacteria increase, which can cause constipation, diarrhea, rough skin and allergies. Past studies have shown that disturbances in the intestinal flora also affect diabetes, obesity, skin wrinkles, and personality, and affect our health. Concentrated whey protein with high IgG antibody content balances the intestinal flora and helps to regulate the intestinal environment by keeping it normal.

Infectious disease prevention

High content of IgG antibodies IgG antibodies, which are contained in high doses in whey protein concentrates, act to inhibit the adhesion of various pathogens to the intestinal tract, thereby protecting against food-borne infections and, in part, respiratory tract infections. It has also been suggested that there is a protective effect against The protective effect of IgG antibody-rich whey protein concentrate against infectious diseases was studied by Juntendo University School of Medicine, and mice given IgG antibody-rich whey protein concentrate were more susceptible to enterohemorrhagic E. coli O157 than controls. H7, indicating resistance to Salmonella (s. Enteritidis). Mice infected with M. avium (a non-tuberculous mycobacterium) and then given whey protein concentrate containing high levels of IgG antibodies showed less bacteria in the lungs compared to the control group.

Prevention of inflammatory bowel disease

You may imagine antibody like a “weapon” that fights against pathogens but there are also some that protect beneficial bacteria. The antibody called Secretory IgA (s-IgA) is a dimer with two IgA antibodies, and most of the IgA antibodies are present in mucous membranes in this form. The s-IgA is not only known to fight in the intestine, but also to protect and colonize beneficial intestinal bacteria, which may prevent the development of inflammatory bowel disease.

Support immune system

Immunity is classified into mucosal immunity that prevents enemies from entering the body, and systemic immunity that fights against enemies that have invaded. IgG is representative of systemic immunity, and s-IgA is representative of mucosal immunity. If this s-IgA is low, pathogenic bacteria can easily invade the body, making it easier to get sick. IgG antibody-rich concentrated whey protein contains not only IgG but also s-IgA and lactoferrin.

Allergy prevention

It is known that about 60-70% of the immune cells in the whole body reside in the intestine. Since the intestine is a place where various harmful substances and pathogens invade, especially many lymphocytes are gathered. And when harmful substances come in, the function to produce s-IgA, which is a representative of mucosal immunity, works to protect us from foreign enemies. It is also said that if the intestinal flora is disturbed at this time, the production of s-IgA will not go well. s-IgA is known to be involved in reducing intestinal inflammation and allergies.

Effects on SARS-CoV-2

It was found that the IgG enriched fraction contains antibodies against SARS-CoV-2 spike (S) and nucleocapsid (N) proteins, and it has indicated that the IgG enriched fraction has cross-reactivity.
Presence of antibodies against SARS-CoV-2 spike protein in bovine whey IgG enriched fraction

Immune activity against bacteria and fungi

Dairy cows raised freely on vast pastures are able to produce antibodies against pathogens by being exposed to various pathogens in their natural environment.

It was published on the journal of “Food Research International” in 2001 that IgG in New Zealand concentrated cow’s milk has immune activity against 19 pathogens (bacteria and fungi).The effectiveness of IgG in New Zealand concentrated cow’s milk against to non-tuberculous mycobacteria, which is now the third leading cause of death in Japan and is increasing year by year, has been proven in vivo by Juntendo University in Japan. The study was reported on the journal of “Food Science & Nutrition” in 2019.

• A comparison of IgG and IgG1 activity in an early milk concentrate from non-immunised cows and a milk from hyperimmunised animals
• Enriched bovine IgG fraction prevents infections with Enterohaemorrhagic Escherichia coli O157:H7, Salmonella enterica serovar Enteritidis, and Mycobacterium avium