Xerosis


Skin structure

Skin is composed of three primary layers: the epidermis, which has contact with the outside; the dermis, which contains sebaceous glands ; and the hypodermis-subcutaneous tissue, which is the bottom layer of the skin.

The "epidermis" plays a role as the barrier against external stimulation such as UV, chemical substance andbacteria.

The "dermis" is a thick layer containing water and secures the skin's firmness and resilience. It consists of collagen, elastin, hyaluronic acid and chondroitin sulphate etc. It provides essential nourishment and helps to make a coat of sebum which protects the skin by secreting sweat and sebum. And it also contains the lymph vessels, blood vessels, nervus, sebaceous glands and root hair etc.

The "hypodermis-subcutaneous tissue" consists almost entirely of subcutaneous fat. It plays an important role as energy storage, a function of maintaining body temperature and a cushion from outside pressures.



Sebum and coat of sebum

Sebum is a lipid substance synthesized by sebaceous cells and its main component is the neutral lipid (triglyceride). When sebum is synthesized in large quantities and beyond the amount of accumulation in a cell, sebaceous cells burst and sebum is extruded into the ducts of the sebaceous gland. The sebum is secreted to the skin surface through the pores, making a coat of sebum covering the skin surface.

The coat of sebum provides moisture and smoothness to skin and hair by preventing them from the evaporation of moisture and it also acts to protect them from external stimulation. Fat contained in sebum is broken down by indigenous bacteria of the skin and fatty acid is produced. Thus the skin surface is kept mildly acid (pH4.2~6.4) which prevents the growth of disease-causing bacteria and the defensive function of skin is enhanced.

The decrease of sebum secretion due to stress or aging leads to the failure of the formation of the sebum coat and can easily get external stimulation. When skin is damaged, the evaporation of skin moisture is stimulated, skin metabolism is distorted, moisturizing and excretory functions also become lower. This then leads to skin problems such as dry skin, tiny wrinkles and skin roughness.


Xerosis (dry skin) and Pruritus (itching)

What is Xerosis?
Dry skin (xerosis) is a condition that is found in all age groups but is most commonly experienced by elderly people. Young children and people using certain drug therapies, for example diuretics and androgen inhibitors, often suffer the disorder but in these cases it may be temporary.
While the description ‘dry skin’ does not sound particularly serious, for those afflicted with the condition it can be quite distressing and certainly uncomfortable. In cases where the skin is exceptionally dry, xerotic eczema can develop with deep cracking of the skin and inflammation adding to the complication. Red, cracked and scaly skin is a symptom of xerosis and the unsightliness caused by this can be distressing for many sufferers. However, it is the itching which is the most aggravating symptom and this can lead to the skin surface being damaged, infection and inflammatory activity due to excessive scratching.

Why does it happen?
The condition is due to a lack of moisture in the skin and tends to be more prevalent in cold, dry winter conditions and air conditioned atmospheres. The areas of the body most commonly affected are the lower legs, back, arms and the waist and abdomen regions.
Xerosis (dorsum of foot)
Xerosis (dorsum of foot)
While environmental conditions aggravate and, in some cases, cause dry skin, our normal body metabolic functions also play an important role. It is changes in some of these functions, in particular hormonal influences on sebaceous gland activity that is one reason for the age related prevalence of the disorder.


The greater prevalence of xerosis in elderly people is due to the age related, natural decline in sebaceous gland production of sebum not adequately maintaining the moisture and oil content of the skin. In males this decline does not really become effective until the age of about 80 but in females it begins after the menopause. Thus women as young as late 50’s or early 60’s are susceptible to the condition.


Asteatotic eczema


1. What is asteatotic eczema?

Asteatotic eczema is a type of eczema that is caused by dry skin that normally develops on the lower legs, lumbar area, buttocks or upper limbs in the elderly.

Xerosis is dry skin resulting from lowered water and sebum secretion which becomes cutaneous pruritus with itchiness when it develops.

Cutaneous pruritus becomes asteatotic eczema with a red rash or sores, as a result of irritation from scratching when it develops further. Early treatment is required for asteatotic eczema, because it progresses to nummular eczema.

It is thought that asteatotic eczema occurs more frequently in the elderly because of an age related reduced ability for moisturizing that is due to the degeneration in intercellular lipids and a decline in sebum secretion. Recently, it has also appeared in young people as a result of excessive bathing and dryness caused by the use of heaters.

2. Cause

The causes of asteatotic eczema are basically the same as those of xerosis and asteaosis. These disorders are attributed to dry skin, not having an adequate sebum coat due to the lowered skin functions and sebum secretion that occur with aging and some disorders.

3. Symptoms

The symptoms of xerosis and asteatosis are dry, rough or cracked skin. In these cases, it is possible to control the symptoms by protecting the skin using a moisturizer. However, the symptoms of asteatotic eczema, which is an advanced stage of xerosis and asteatosis, are severe itchiness and red eczema caused by scratching.

4. Treatments

Mild casesUse moisturizing ointments for itching areas, because it is caused by the skin drying up.
Vaseline, hydrophilic ointmentIt makes a coat to prevent water evaporation. It is very safe but greasy.
Urea preparationIt retains water in the stratum corneum.Very safe and low cost. It will produce a slight pain upon application.
Heparin-like substanceIt retains water in the stratum corneum.
Severe eczema casesUse topical corticosteroid. Use antihistamine agent or antiallergic agent for itching areas.
Cases of sleep disturbance due to itching.Administration of minor tranquilizers such as diazepam (Cercine®), ethyl loflazepate (Meilax®) or hydroxyzine (Atarax-P®).


The treatment by asteatotic eczema is required on a long term basis because the symptoms are age related and difficult for a full recovery.
Care of xerosis, asteatosis and asteatotic eczema


Age-related asteatosis and xerosis are inevitable to some extent. However, for relieving symptoms even if only slightly, daily skincare and maintenance of the living environment are important. The considerations of asteatotic eczema in everyday life are basically the same as the considerations of asteatosis, due to the fact that asteatotic eczema often occurs with the deterioration of asteatosis. However, the drug treatments for asteatotic eczema and asteatosis are different.

1. When taking a bath or a shower

When taking a bath or a shower, you have to get rid of extra corneum on the surface of the skin as well as dirt (dust, oil etc) while washing your body. In doing so, please note the following :

  1. If the skin is strongly scrubbed, more sebum is removed than necessary. Moreover, the barrier of stratum corneum is damaged. Do not scrub more than necessary. To keep precious sebum, you should briefly try to wash your skin very gently, with a soft towel or your hands. It's better not to use a washcloth made with nylon or a pumice stone. In addition, try to avoid using too much soap and washing an area too long.
  2. Rinse your skin thoroughly so that there is no remaining soap or shampoo.
  3. It's better to use a solid soap, which has a weak degreasing power, not a body shampoo. Using a body shampoo, the used amount of surfactant at once is too much compared to a solid soap. In addition, too much sebum in the skin is removed, and it can not rinse properly.
  4. You should take lukewarm baths under 40℃, due to the fact that not only does a warm body increase itching but hot water also strongly irritates the skin and decreases the moisturizing functions.
  5. Try to avoid taking a long bath, to prevent the efflux of sebum.
  6. People who have dry skin should devise a plan, such as bathing once every 2 days.
2. To moisture skin

If the sebum is washed out by taking a shower or a bath, skin moisture increasingly evaporates and the skin dries more easily. This is due to the decline in the sebum lipogenesis ability in the case of asteatosis and asteatotics. So you need to use a moisturizer to moisten the skin. When there is still moisture in the skin after taking a shower or a bath, you should apply a moisturizer gently. There are a lot of commercial moisturizers available, you should select a moisturizer that best suits your skin type. Though the duration of moisture-retaining ability is different depending on the moisturizer, you need to apply these frequently to some extent. In addition, using moisturizing bath agents is also effective.

3. To reduce skin irritation

  1. In the case of asteatosis and asteatotic eczema, even weak irritation induces an itchiness. Therefore it is important to avoid wearing irritating cloth materials such as wool or nylon and best to wear cotton cloth which is highly hygroscopic and soft.
  2. To prevent remaining laundry detergent in washed clothes, they need to be rinsed properly.
  3. Keep away from cold water, chemical detergent and chemical fiber such as nylon as much as you can.
  4. Do not directly apply a plaster or tape etc on the affected area.
4. To maintain a humidity in a room

The dryness of the air often has the tendency to make your skin dry, especially when using a heater in a closed room because the humidity level will suddenly lower. It's better to make the air in the room moist, by letting in fresh air, using a humidifier, boiling a full kettle of water and putting a wet towel in the room (It is important to maintain the humidity level of the room to around 50-60%).

5. Sleep

You should have plenty of sleep. When using an electric blanket or underblanket please note there is too much heat. Because it will increase itchiness by facilitating the flow of blood as well as progressing dry skin due to the evaporation of skin moisture.

6. Diets

  1. You should regularly eat a balanced and digestible diet.
  2. Please refrain from taking any stimulants such as alcohol and spicy foods, because sometimes these foods can make the body warm and enhance itching.
  3. Try to avoid diets such as hot temperature foods, strong tasting foods and using foods which include scum (bamboo shoots, eggplants, yam and aroids).
7. To prevent scratching

You should keep your nails short and should not scratch affected areas, because scratching will definitely make symptoms worse. If you have severe itching with asteatotic eczema, cooling the affected area is an effective way in reducing the itchiness.

8. Exercise

Try to build up a sweat with daily exercise, this will build up the strength of your sweat glands and make it easier for sweat to be released through your sweat glands. Sweat is a component on your skins’ sebum coat. It is also effective to refresh your body by taking a bedrock bath or a half body bath.

9. Stay sharp

You need to continue skin care at least during the period when symptoms occur frequently (during winter). Even if the symptoms improve, the skin will return to the original dry condition immediately after stopping the skin care. During the summer if your skin doesn’t feel dry, you should occasionally continue the skincare to prevent the symptoms which will occur in the following autumn to winter that year. Before your symptoms become severe, you should protect your skin with the use of moisturizers such as Vaseline when you feel your skin drying, the reason being that symptoms become worse every year with the approach of winter.

10. Please talk to a skin specialist

In the earlier phases of asteatosis, all you have to do is perform the measures mentioned above to maintain good skin condition to some extent. However, once you get skin inflammation, itchiness continues or skin conditions do not improve. In that case, you will need to be treated with moisturizer to make up for decreased lipid components and external medicine for itchiness and eczema. There are times when you will need to take internal medicine too, such as when you have severe itchiness. When you have severe symptoms or get eczema, please talk to a skin specialist.

11. Medication

  1. You should use prescribed medication following the dosage and administration.
  2. The application agent should be applied thinly and lightly.
  3. An ointment is more effective than a cream from the point of view of the supplement lipid components.
12. Sebum lipogenesis stimulation

The cause of asteatosis and asteatotic eczema is the decline in sebum lipogenesis ability. It has been proved that Maitake mushroom extract (lipid) enhances sebum lipogenesis of diminished sebaceous cells and stimulates sebum lipogenesis in sebaceous cells (in both the in vivo and in vitro experiments). Using this product is also effective in maintaining skin condition, which is not like existing cosmetics that protect the skin and preserve the skin moisture by applying moisturizer. The product that includes Maitake mushroom extract stimulates skin moisture itself and enhances the ability of self-defense by activating intrinsic sebum lipogenesis ability.

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